A Prospective Trial to Study the Evolution of Clonal Architecture of Tumors From Patients Treated With Molecular Targeted Agents

Inclusion Criteria: Patients diagnosed with confirmed cancer and who fulfill the following eligibility criteria will be considered eligible for this study: 1. Patient affiliated to a social security regimen 2. Patients scheduled to receive anticancer agents or currently receiving anticancer agents 3. Tumor lesion accessible to core biopsies (malignant effusions can represent an alternative) 4. Patient who is fully informed, able to comply with the protocol and who signed the informed consent. 5. Availability of initial tumor material (ideally frozen, or non-Bouin fixed paraffin embedded material) acquired before exposure to the targeted therapy Note: Patients may have received other treatments since treatment with targeted therapies including radiation or chemotherapy, before undergoing the study biopsy. Exclusion Criteria: 1\. Coagulation abnormality prohibiting a biopsy