The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).
The investigators propose the following two specific aims in a randomized crossover placebo-controlled trial in participants with two or more features of the metabolic syndrome and symptomatic osteoarthritis in this 12-week efficacy study: Aim 1: To assess the effects of strawberries on biomarkers of inflammation \[serum levels of C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β; tumor necrosis factor-alpha: TNFα\] Aim 2: To assess the effects of strawberries on knee function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and HAQ-DI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
20
Natural frozen and dried strawberries
Placebo powder matched for carbohydrates and fiber in the strawberries
Oklahoma State University
Stillwater, Oklahoma, United States
Pain Scores on the Visual Analog Scale
Time frame: six months
Inflammatory Biomarkers in Serum
Time frame: six months
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