Obstructive Sleep Apnoea and Adipose Tissue Dysfunction

Royal Devon and Exeter NHS Foundation Trust15 enrolled

Overview

Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.

Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obstructive Sleep Apnoea Obesity Hypoxia

Interventions

overnight use of CPAP device

Eligibility

Sex: MALEMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * men with or without obstructive sleep apnoea Exclusion Criteria: * weight loss interventions * steroid use * active smoking

Locations (2)

NIHR Clinical Research Facility

Exeter, United Kingdom

Royal Devon and Exeter NHS Foundation Trust

Exeter, United Kingdom

Outcomes

Primary Outcomes

pO2 in adipose tissue by Clarke type electrode

Measurement of pO2 by Clarke type electrode

Time frame: 4 months

Secondary Outcomes

blood flow in adipose tissue by laser Doppler techniques

assessment of tissue blood flow by laser Doppler techniques

Time frame: 4 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.