Influence of Emotional Disorders and Executive on the Components Retrograde and Anterograde Episodic Memory in MS

University Hospital, Caen80 enrolled

Overview

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system responsible for physical disability but can also cause cognitive disturbances annoying social and professional life of patients with the disease. Various studies have shown that there was a breach of episodic memory, working memory, attention and executive functions regardless of the form of disease, disability or duration of disease progression. The main objective of this study is to investigate the influence of emotional components and executive processes on the components retrograde and anterograde episodic memory (thanks to an original paradigm based on the emotional valence of the memory) in MS patients

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Multiple Sclerosis

Interventions

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and women 30-60 years of age * Definite MS (McDonald criteria revised in 2005) * EDSS \<6 * Sick Shapes: Relapsing multiple sclerosis, Primary progressive multiple sclerosis * All durations evolution * French Mother tongue * Signature of informed consent Exclusion Criteria: * Other neurological conditions, previous psychiatric or developmental diagnosis of MS * Head injury sequelae * Chronic alcohol or drugs Taking * EDSS greater than or equal to 6 * Secondary Progressive Form * Push and / or treatment with corticosteroids within one month * Treatments Amantadine, Modafinil introduced for less than 3 months * Patient Trust * Cognitive Assessment of less than one year (including in particular all or part of the balance sheet proposed in this project) * Any visual motor deficit or incompatible with the award of cognitive tests * For women, pregnancy, breastfeeding and / or lack of contraception (a pregnancy test will be done before the PET scan) * Patient with indications against MRI

Outcomes

Primary Outcomes

anterograde episodic memory: 3 scores of emotional ESR

3 scores of emotional ESR

Time frame: baseline

retrograde episodic memory: 9 scores TEMP emotional

9 scores TEMP emotional