NPWT PRO vs KCI Ulta® NPWT and to Compare NPWT PRO vs NPWT PRO With Simultaneous Irrigation on Wound Healing

Inclusion Criteria: * Presents with an existing chronic or traumatic wound, sub-acute or dehisced wound, partial-thickness burn, ulcer (such as a diabetic or pressure ulcer), flap or graft as diagnosed by a qualified and certified medical practitioner (M.D., D.O., or D.P.M) * Wound presents with full thickness loss of epidermis and dermis * The presentation of a wound that in the opinion of the investigators will require surgical debridement, and the wound is expected to be a good candidate for NPWT and eventual wound closure. * ABI≥0.5 or toe pressures \>30 PVR/mmHg * Subject is willing and able to abstain from partaking in any other form of treatment for his or her wound throughout the duration of his or her course of participation in the clinical study, other than the study procedures described herein. * 18 years of age or older Exclusion Criteria: * Does not present with an existing chronic or traumatic wound, sub-acute or dehisced wound, partial-thickness burn, ulcer (such as a diabetic or pressure ulcer), flap or graft, or a definitive diagnosis cannot be made, as diagnosed by a qualified and certified medical practitioner (M.D., D.O., or D.P.M) * Wound does not present with full thickness loss of epidermis and dermis * ABI\<0.5 or toe pressures \<30 PVR/mmHg * Subject is not willing or is not able or it is not medically prudent for the subject to abstain from partaking in any other form of treatment for his or her wound throughout the duration of his or her course of participation in the clinical study, other than the study procedures described. * Subject is unwilling or unable to use the NPWT device at home * Active Charcot arthropathy * Collagen vascular disease * Scleroderma * Non-enteric and unexplored fistula * Necrotic tissue with eschar present after debridement * General skin disorder in the area of the wound such as psoriasis or penicilitis * Malnutrition (defined as BMI \<19) * Hypercoagulable state based on documentation in their medical record * Acute deep vein thrombosis * Current active malignancy in the wound * Current melanoma or history of melanoma at the wound * Current active or history of invasive squamous cell carcinoma at the wound * Sepsis (defined as positive blood culture with leukocytosis) and temperature \>101.5 at the time of screening * Significant Hematologic disorders EXCLUDING anemia * HIV * Fever at screening \> 101.5 * Deep X-ray therapy * Untreated bone or soft tissue infection (osteomyelitis) * Any concomitant illness(es) or medical condition(s) that in the opinion of the investigator would render the subject not suited for study participation * Subject is taking a regimen of any medication(s) in a significant enough dosage that may affect chronic wound healing, including corticosteroid, chemotherapeutic and non-steroidal anti-inflammatory (NSAID) medications * Less than 18 years of age * Developmental disability/significant psychological disorder that could impair the subject's ability to provide informed consent, participate in the study protocol or record study measures, including schizophrenia, bipolar disorder and psychiatric hospitalization within the last 2 years. * Females currently pregnant or planning pregnancy during the course of intended participation in the study * Active alcohol or substance abuse in the opinion of the investigator that could impair the subjects ability to provide informed consent, participate in the study protocol or record study measures.