Non-inferiority Study Comparing Firehawk Stent With Abbott Xience Family Stent (TARGET-AC)

Inclusion Criteria: * Minimal age 18 years * Symptomatic coronary artery disease * Patient acceptable candidate for treatment with drug eluting stent in accordance with applicable guidelines * Presence of one or more coronary artery stenosis \>50% with reference diameter 2.25-4.0mm which can be covered by one or multiple stents * Patient indication, lesion length and vessel diameter according to 'Instructions for Use' of study stents * Patient is willing and able to cooperate with study procedures and required follow up visits and patient or legal representative has been informed and agrees by signing EC approved written informed consent Exclusion Criteria: * Women of childbearing potential who do not have a negative pregnancy test within 7 days before procedure and women who are lactating * Known intolerance to aspirin, clopidogrel or ticlopidin, heparin, cobalt, nickel, chromium, molybdenum, polymer coatings, Sirolimus, Everolimus, or contrast material * Participating in other trial before reaching primary endpoint * Planned surgery within 6 months of PCI unless dual antiplatelet therapy is maintained throughout the peri-surgical period.