Endostar Aggressive Treatment of Peripheral T-cell Lymphoma (PTCL) Phase II Clinical Study

Inclusion Criteria: 1. Newly diagnosed or relapsed PTCL patients by pathology, and / or cytology examination, which are required to receive chemotherapy; 2. At least 1 single size measurable lesions, CT, MRI, Bultrasound scan or PET-CT scan shows more than 15mm； 3. Physical condition is good: ECOG score between 0-2 points； 4. The expected survival time is more than 3 months； 5. Age 18 years or older,unlimited gender； 6. Fit chemotherapy indications and basic requirements, including normal peripheral hemogram,no obvious abnormal function of heart, liver and kidney, normal ECG;no great trauma without healing； The test indicators must fit the following requirements: Cardiac ultrasound LVEF≥50%； Peripheral blood：WBC≥3.5×109/L，PLT≥70×109/L，Hb≥80g/L Renal function：Cr≤2.0×UNL（Upper limit of normal value） Liver function：BIL≤2.0×UNL，ALT/AST≤2.5×UNL 7. No serious allergic reaction to biological agents, especially E. coli gene engineering products； 8. Voluntary participation, good compliance, cooperate with the experimental observation, and sign a written informed consent。 Exclusion Criteria: 1. Inert T cell lymphoma (such as mycosis fungoides /Sezary syndrome), ALK positive anaplastic large cell lymphoma； 2. Patients who received chemotherapy drugs in the past; 3. Pregnant women,lactating women,or having fertility but not taking contraceptive measures； 4. Patients with serious uncontroled acute infection;or suppurative and chronic infection and unhealing wound； 5. Patients with original serious heart disease, including: high-risk cardiac arrhythmias of congestive heart failure,uncontroled instability angina, myocardial infarction and severe heart valve disease and intractable hypertension； 6. Patients with less control of the nervous, mental illness or mental disorders, poor compliance, and the description of the treatment response； 7. Patients with primary central nervous system lymphoma or lymphoma involving central nervous system； 8. Patients with abnormal coagulation function and severe thrombosis; 9. Patients who participated in other clinical trials； 10. The researchers considered that patients should not be in this trial。