A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors

Inclusion Criteria: Patients must have: * advanced solid tumors and have confirmed cMET dysregulation * at least one measurable lesion as defined by RECIST 1.1. * recovered from all toxicities related to prior anti-cancer therapies * adequate organ function * ECOG performance status (PS) of 0 or 1 Exclusion Criteria: Patients must not have: * known hypersensitivity to any of the excipients of INC280 or to benzodiazepines or known intolerance and hypersensitivity to caffeine * symptomatic central nervous system (CNS) metastases who are neurologically unstable * presence or history of carcinomatous meningitis * history of another primary malignancy that is currently clinically significant or currently requires active intervention * Clinically significant, uncontrolled heart diseases, including QTcF ≥ 450 ms (male patients), ≥ 460 ms (female patients) on the screening ECG * Thoracic radiotherapy to lung fields ≤ 4 weeks prior to starting INC280 * Major surgery within 4 weeks prior to starting INC280 * Patients receiving unstable or increasing doses of corticosteroids. * Impairment of GI function or GI disease that may significantly alter the absorption of INC280 * Patients who have received or consumed, or are expected to receive or consume midazolam or caffeine-containing products (e.g., tea, coffee, cola), within 2 days prior to Day 1 and during the whole duration of the DDI phase (i.e., from Day -2 to Day 12) Other protocol-defined inclusion/exclusion criteria may apply