Bedrest, Feeding Pattern, and Insulin Sensitivity

Maastricht University Medical Center20 enrolled

Overview

In the present study, the investigators will assess the impact of two different feeding patterns (continuous vs intermittent) on insulin sensitivity and muscle mass following bedrest.

In the present study, the investigators will assess the impact of two different feeding patterns on insulin sensitivity and muscle mass following bedrest. Healthy, young males will be fed in a continuous (no breaks in food supply) or intermittent (in boluses throughout the day) manner.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Atrophy, Disuse Insulin Resistance

Interventions

Intermittent feeding patternOTHER

Intermittent feeding

Continuous feeding patternOTHER

Continuous feeding

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 18.5 and 35 * Recreationally active Exclusion Criteria: * Type 2 diabetes * Performing progressive resistance training in 6 months prior to study * Back/knee/leg problems * Hypertension * Use of certain anticoagulants * All co morbidities interacting with mobility and muscle metabolism of the lower limbs * Blood donation in past 3 months

Locations (1)

Maastricht University Medical Center+

Maastricht, Limburg, Netherlands

Outcomes

Primary Outcomes

Change in insulin sensitivity (measured as glucose infusion rate during hyperinsulinaemic-euglycaemic clamp)

Time frame: 7 days bedrest

Secondary Outcomes

Change in muscle mass (measured as upper leg muscle cross-sectional area with CT scan)

Via single-slice CT scan

Time frame: 7 days bedrest

Change in lean tissue (measured via DEXA scan)

Via DEXA

Time frame: 7 days bedrest

Data from ClinicalTrials.gov

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