Clinical Trial Assessing the Value of an Antibiotic Protocol Guided by Serum Procalcitonin in Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Intensive Care

Inclusion Criteria: * patients over 18 years * Documented or suspected clinically COPD according to the criteria of GOLD * In acute exacerbation * Suspect of lower respiratory tract infection * With or without pulmonary criteria defined as the presence of a radiological infiltrates consistent with an infectious site and associated with one or more of the following items: dyspnea, cough, sputum, fever above 38 ° C, fireplace clinical auscultation, higher leukocytosis at 10,000 / mm³ or leukopenia below 4000 / mm³ * Admitted to the hospital for less than 48 hours * ICU Admission * Informed Consent signed by the patient or his representative Exclusion Criteria: * Other than acute exacerbation etiology with or without pulmonary disease as suspected cause of ICU admission * Patient immunocompromised neutropenia neutrophil count below 500 / mm³ secondary to chemotherapy, corticosteroids greater than 0.5 mg / kg / day for more than 10 days, HIV seropositivity * Severe Acute Asthma * Moribund patient or a disease with an estimated survival time of less than three months * Therapeutic limitation Existence * minor patient or under guardianship or custody * Pregnant woman * Refusal to participate in the study * The inclusion of the subject in another biomedical research protocol in progress or for less than 30 days