Evaluation of ColdZyme® Mouth Spray on Prevention and Alleviation of Rhinovirus Induced Common Cold

Inclusion Criteria: 1. Healthy male or female subjects between 18-65 years. The investigator judges the definition of healthy by detailed medical history and physical examination. 2. Females of childbearing potential: should use reliable method of birth control. Reliable methods are hormonal contraceptives (combination pills, injections or implants), intrauterine device, condom or declared absence of sexual contact. Post-menopausal woman is defined as absence of menstrual discharge for at least two years. 3. Signed informed consent form prior to any study-related procedures. 4. Willingness and ability to complete the study. 5. Perceived to have had at least one cold per year. Exclusion Criteria: 1. Smoker, during the last 12 months. 2. Any cold symptom within the last month such as sore throat, sneezing, rhinorrhoea, malaise, nasal obstruction or cough. 3. Presence of serum neutralising antibodies against human rhinovirus16 at screening. 4. Active allergic rhinitis, asthma or chronic obstructive pulmonary disease in last year. 5. Positive for fur allergy (if subject is likely to come in contact with the specific pet) and/or dust-mite allergy in skin prick test at screening. 6. Nasal disease, e.g. nasal polyposis, significant septal deviation, chronic rhinosinusitis, etc. 7. Females: Pregnant, breast-feeding or intentions to become pregnant during the study. 8. Active autoimmune disease in last year. 9. Evidence or history of drug or alcohol abuse. 10. Use of any prescribed or non-prescribed medication (except for contraceptives, paracetamol and ibuprofen) within 2 weeks prior to the first administration of investigational product until the end of study. 11. Use of any over the counter cold prophylaxis products such as C-vitamins, zinc or Echinacea within 1 month prior to the first administration of investigational product until the end of study. 12. Participation in other clinical study within 60 days