The purpose of this study is to evaluate the efficacy and adverse effect of nebulized corticosteroid to prevent post-extubation stridor in children.
The guideline for prevention and treatment of post-extubation stridor in children is inconclusive include Nebulized epinephrine and intravenous corticosteroid. Nebulized corticosteroid is alternative treatment for viral croup. the rationale of this study to evaluate the efficacy of nebulized fluticasone propionate to prevent pediatric post-extubation stridor
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
144
Flixotide 1 mg + NSS upto 4 ml nebulized after extubation. Record vital signs and modified Westley score at 0, 15, 30, 60 min and 2,4,6 hours
NSS 4 ml nebulized after extubation. Record vital signs and modified Westley score at 0, 15, 30, 60 min and 2,4,6 hours
Department of Pediatric,Ramathibodi Hospital
Bangkok, Thailand
post-extubation stridor
patient who developed stridor after extubation within 6 hours
Time frame: 6 hours
treatment failure
patient who required escalating of respiratory support such as noninvasive positive pressure ventilation or reintubation within 24 hours
Time frame: 24 hour
adverse events
hyperglycemia, oral thrust or GI bleeding
Time frame: 24 hour
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