Safety and Efficacy of Doxorubicin-eluting-bead Embolization in Patients With Advanced Hepatocellular Carcinoma

Inclusion Criteria:\[Stage C HCC according to the BarcelonaClinic of Liver Cancer\] 1. Signed written informed consent. 2. Clinical or histological diagnosis of HCC based on the guidelines of the American Association for the Study of Liver Diseases. 3. At least one typical enhanced lesion that is bi-dimensionally measurable by multiphasic spiral CT scan or dynamic contrast-enhanced MRI. 4. Tumor conditions confirmed by abdominal imaging (contrast enhanced CT ± MRI) performed within 1 month prior to the enrollment: 5. Age of at least 18 years and less than 80 years. 6. ECOG Performance Status of 0 or 1. 7. Child-Pugh class A or B (Child-Pugh score ≤ 7). 8. Life expectancy of at least 16 weeks. 9. Adequate bone marrow, liver, and renal function as assessed by the following laboratory requirements (no transfusion, no restoration), conducted within 14 days prior to screening: * Hemoglobin ≥ 8.0 g/dL * Absolute neutrophil count ≥ 1,000/mm3 * Platelet count ≥ 50,000/μL * Total bilirubin \<2.5 mg/dL * Serum albumin ≥2.8 g/dL * ALT and AST \< 5 × upper limit of normal * PT-INR ≤ 2.3 or Prothrombin Time-sec ≤ 6 sec * Serum creatinine ≤ 1.7 mg/dL Exclusion Criteria: 1. A history of receiving any systemic therapy of the molecularly targeted agents, immunotherapy or cytotoxic chemotherapy for the treatment of HCC 2. Invasion of inferior vena cava (Vv3), or invasion of first order branch of the biliary duct (B3) 3. History or presence of hepatic encephalopathy 4. Ascites, moderate, large or intractable 5. Active clinically serious infections (\> grade 2, NCI-CTC version 4.0), including spontaneous bacterial peritonitis. 6. Untreated active chronic hepatitis B 7. Esophageal or gastric varices≥ F2 (grade 2) with red color sign positive without prophylaxis (non-selective beta-blocker or endoscopic variceal ligation) or history of variceal bleeding without endoscopic variceal ligation/ injection sclerosis 8. Active ulcer of stomach or duodenum: untreated or presence of visible vessel 9. Any major surgery within 4 weeks, or any minor surgery within 2 weeks prior to signing the informed consent form 10. Candidate for liver transplant and a history of liver transplantation 11. History of cardiac disease: congestive heart failure greater than NYHA class 2; active coronary artery disease; cardiac arrhythmias requiring anti-arrhythmic therapy or uncontrolled hypertension and diabetes mellitus 12. History of AIDS/HIV infection. 13. Seizure disorder requiring medication. 14. History of organ allograft. 15. Evidence or history of bleeding diathesis, or thromboembolic events requiring treatment 16. Current renal dialysis. 17. Previous or concurrent cancer that has a primary site or histology distinct from HCC, except cervical carcinoma in situ, treated basal cell carcinoma, superficial bladder tumors \[Ta, Tis, and T1\] or any cancer curatively treated less than 3 years prior to enrollment. 18. History of alcohol abuse (male \> 210g/week, female \>140g/week) 19. Any contraindication for chemoembolization except major branch of portal vein invasion 20. Any contraindication for doxorubicin administration