Aprepitant Versus Gabapentin Prophylaxis for Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgeries

Assiut University150 enrolled

Overview

To evaluate the efficacy of pre-empetive administration of Aprepitant, Versus Gabapentin prophylaxis for reducing the incidence of postoperative nausea and vomiting in Laproscopic gynacological surgeries.

Postoperative nausea and vomiting (PONV) is frequently encountered in the surgical recovery room. Laparoscopic surgery is one important risk factor for increased incidence of PONV. Gabapentin, an anticonvulsant with known postoperative analgesic properties, has shown some activity against PONV. Results from clinical trials evaluating the anti-emetic efficacy of gabapentin are conflicting. Aprepitant, a neurokinin-1 (NK1) receptor antagonist, blockades the central effects of substance P. Substance P is a neurotransmitter found in central areas associated with emesis such as the dorsal vagal complex and area postrema.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

150

Conditions

Postoperative Nausea and Vomiting

Interventions

dexamethasoneDRUG

dexamethasone 8 mg iv 2 minutes before induction of anesthesia

GabapentinDRUG

oral gabapentin 600 mg 1 hour before induction of anesthesia

AprepitantDRUG

oral aprepitan 80mg 1 hour before induction of anesthesia.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: • ASA physical status I and II aged between 18 and 45 yrs. They undergo Laproscopic gynacological surgeries under general anesthesia. Exclusion Criteria: * Central or peripheral neurological pathologies. * History of drug abuse, chronic pain, or psychiatric disorders. * Pregnant women * Patients who took sedatives, antiemetics, or antipruritics within 24 hrs of operation.

Locations (1)

Hala saad Abdel-Ghaffar

Asyut, Assiut Governorate, Egypt

Outcomes

Primary Outcomes

incidence (%) of postoperative nausea and vomiting

The incidence (%) of PONV will be recorded each 6 hours until 24 hours after discharge from the PACU.

Time frame: 24 hours postoperative

Secondary Outcomes

non invasive blood pressure

Noninvasive blood pressure measured immediately after induction of anesthesia ,15 min.30 min.45 min. and 60 min till the end of surgery

Time frame: intra-operative from induction of general anesthesia till end of surgery.

heart rate

heart rate recorded immediately after induction of anesthesia ,15 min.30 min.45 min. and 60 min till the end of surgery

Time frame: Intra-operative from induction of anesthesia till end of surgery.

side effects

Side effects of given drugs will be treated and recorded

Time frame: 24 h postoperative.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.