The purpose of this study is to understand if there is a relationship between the way that emotions are regulated by the brain and the way that heart rate is regulated by the brain. The study also seeks to understand whether having depression changes the way that emotions and heart rate are regulated.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
8
Subjects are asked to watch a series of six two-minute video clips. The video clips are designed to induce sad or happy emotions or no emotion (neutral) and are taken from movies, documentaries, or instructional videos. There are two videos for each emotion condition. Videos and fixation cross screens are viewed on a laptop computer. In between video clips, patients are asked to quietly look at a fixation cross for one minute, describe their emotional reaction to the video for up to one minute, then again attend to a fixation cross for one minute. A video recording of the frontal view of the participant's face will be made during task performance.
Subjects are asked to think about happy or sad memories for 2 minutes. Subjects are asked to imagine performing neutral tasks, such as buying groceries. Subjects are then asked to think about a memory that makes them feel angry. A video recording of the frontal view of the participant's face will be made during task performance.
Emory University Hospital
Atlanta, Georgia, United States
12 Executive Park Drive
Atlanta, Georgia, United States
Emory University at Wesley Woods Hospital
Atlanta, Georgia, United States
Change in heart rate variability (HRV, also called RSA)
HRV is measured as the variations of the time interval between two consecutive cardiac beats registered by means of electrocardiogram (EKG). Change is the difference from between HRV at baseline and after video task.
Time frame: Baseline, Post-Video Task Session 1 (30 minutes)
Change in heart rate variability (HRV, also called RSA)
HRV is measured as the variations of the time interval between two consecutive cardiac beats registered by means of electrocardiogram (EKG). Change is the difference from between HRV at baseline and after the imaginal task.
Time frame: Baseline, Post-Imaginal Task Session 1 (6 minutes)
Change in heart rate variability (HRV, also called RSA)
HRV is measured as the variations of the time interval between two consecutive cardiac beats registered by means of electrocardiogram (EKG). Change is the difference from between HRV at baseline and after video task one week post-infusion.
Time frame: Baseline, Post-Video Task Session 2 (30 minutes)
Change in heart rate variability (HRV, also called RSA)
RSA is measured by changes in the R-R interval (time between two of the distinctive, large, upward "R" spikes on an electrocardiogram (EKG)) synchronized with respiration. Change is the difference from between RSA at baseline and after imaginal task one week post-infusion.
Time frame: Baseline, Post-Imaginal Task Session 2 (6 minutes)
Mean values of positive emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
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Time frame: Post-Video Task Session 1 (30 minutes)
Mean values of positive emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Imaginal Task Session 1 (6 minutes)
Mean values of negative emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Video Task Session 1 (30 minutes)
Mean values of negative emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Imaginal Task Session 1 (6 minutes)
Mean values of positive emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Video Task Session 2 (30 minutes)
Mean values of positive emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Imaginal Task Session 2 (6 minutes)
Mean values of negative emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Video Task Session 2 (30 minutes)
Mean values of negative emotional expressions
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the probability of expression of certain emotional states (e.g. neutral, positive, negative).
Time frame: Post-Imaginal Task Session 2 (6 minutes)
Mean activation of muscle action units
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the activation of facial muscle action units.
Time frame: Post-Video Task Session 1 (30 minutes)
Mean activation of muscle action units
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the activation of facial muscle action units associated with smiling.
Time frame: Post-Imaginal Task Session 1 (6 minutes)
Mean activation of muscle action units
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the activation of facial muscle action units associated with smiling.
Time frame: Post-Video Task Session 2 (30 minutes)
Mean activation of muscle action units
Automated analysis of video data of facial expressions will be carried out using iMotions software (iMotions Inc, Cambridge, MA). This software can calculate the activation of facial muscle action units associated with smiling.
Time frame: Post-Imaginal Task Session 2 (6 minutes)
Change in heart rate
Heart rate will be measured with the electrocardiogram (EKG) and recorded in beats per minute. Change is the difference from between heart rate at baseline and after the video task.
Time frame: Baseline, Post-Video Task Session 1 (30 minutes)
Change in heart rate
Heart rate will be measured with the electrocardiogram (EKG) and recorded in beats per minute. Change is the difference from between heart rate at baseline and after the imaginal task.
Time frame: Baseline, Post-Imaginal Task Session 1 (6 minutes)
Change in heart rate
Heart rate will be measured with the electrocardiogram (EKG) and recorded in beats per minute. Change is the difference from between heart rate at baseline and after the video task one week post-infusion.
Time frame: Baseline, Post-Video Task Session 2 (30 minutes)
Change in heart rate
Heart rate will be measured with the electrocardiogram (EKG) and recorded in beats per minute. Change is the difference from between heart rate at baseline and after the imaginal task one week post-infusion.
Time frame: Baseline, Post-Imaginal Task Session 2 (6 minutes)
Change in skin conductance response (SCR)
The skin conductance will be measured between two leads attached to the participant's the left and right palms which records electrodermal measures. Change is the difference from between SCR at baseline and after the video task.
Time frame: Baseline, Post-Video Task Session 1 (30 minutes)
Change in skin conductance response (SCR)
The skin conductance will be measured between two leads attached to the participant's the left and right palms which records electrodermal measures. Change is the difference from between SCR at baseline and after the imaginal task.
Time frame: Baseline, Post-Imaginal Task Session 1 (6 minutes)
Change in skin conductance response (SCR)
The skin conductance will be measured between two leads attached to the participant's the left and right palms which records electrodermal measures. Change is the difference from between SCR at baseline and after the video task one week post-infusion.
Time frame: Baseline, Post-Video Task Session 2 (30 minutes)
Change in skin conductance response (SCR)
The skin conductance will be measured between two leads attached to the participant's the left and right palms which records electrodermal measures. Change is the difference from between SCR at baseline and after the imaginal task one week post-infusion.
Time frame: Baseline, Post-Imaginal Task Session 2 (6 minutes)
Change in respiration rate
The respiration rate will be measured by the respiration monitor belt and recorded as number of breaths per minute. Change is the difference from between respiration rate at baseline and after the video task.
Time frame: Baseline, Post-Video Task Session 1 (30 minutes)
Change in respiration rate
The respiration rate will be measured by the respiration monitor belt and recorded as number of breaths per minute. Change is the difference from between respiration rate at baseline and after the imaginal task.
Time frame: Baseline, Post-Imaginal Task Session 1 (6 minutes)
Change in respiration rate
The respiration rate will be measured by the respiration monitor belt and recorded as number of breaths per minute. Change is the difference from between respiration rate at baseline and after the video task one week post-infusion.
Time frame: Baseline, Post-Video Task Session 2 (30 minutes)
Change in respiration rate
The respiration rate will be measured by the respiration monitor belt and recorded as number of breaths per minute. Change is the difference from between respiration rate at baseline and after the imaginal task one week post-infusion.
Time frame: Baseline, Post-Imaginal Task Session 2 (6 minutes)
Change in pulse rate
The peripheral pulse rate will be measured by pulse oximeters placed on one finger on the left and right hands. Change is the difference from between pulse rate at baseline and after the video task.
Time frame: Baseline, Post-Video Task Session 1 (30 minutes)
Change in pulse rate
The peripheral pulse rate will be measured by pulse oximeters placed on one finger on the left and right hands. Change is the difference from between pulse rate at baseline and after the imaginal task.
Time frame: Baseline, Post-Imaginal Task Session 1 (6 minutes)
Change in pulse rate
The peripheral pulse rate will be measured by pulse oximeters placed on one finger on the left and right hands. Change is the difference from between pulse rate at baseline and after the video task one week post-infusion.
Time frame: Baseline, Post-Video Task Session 2 (30 minutes)
Change in pulse rate
The peripheral pulse rate will be measured by pulse oximeters placed on one finger on the left and right hands. Change is the difference from between pulse rate at baseline and after the imaginal task one week post-infusion.
Time frame: Baseline, Post-Imaginal Task Session 2 (6 minutes)