This pilot clinical trial studies perfusion magnetic resonance imaging in diagnosing patients with kidney tumors. Diagnostic procedures, such as perfusion magnetic resonance imaging, may help find and diagnose kidney tumors and predict and monitor a patient's response to treatment.
PRIMARY OBJECTIVES: I. To investigate the utility of perfusion magnetic resonance imaging (pMRI) as a diagnostic biomarker for the prediction of malignant vs. benign organ confined renal masses. II. To investigate the utility of pMRI as a therapeutic biomarker for monitoring tumor progression in patients undergoing treatment (ablation, surgery, specific systemic treatments such as interleukin 2 (IL-2) or vascular endothelial growth factor \[VEGF\]/vascular endothelial growth factor receptor \[VEGFR\]/mechanistic target of rapamycin \[mTOR\] targeted therapies) or active surveillance for organ confined or metastatic renal tumors. SECONDARY OBJECTIVES: I. To investigate the utility of pMRI to predict tumor grade and histologic subtype of organ confined kidney cancers. OUTLINE: Patients undergo dynamic contrast enhanced (DCE), dynamic susceptibility contrast (DSC), or arterial spin labeled (ASL) pMRI within 30 days of biopsy or surgery. Patients with organ confined tumors selected for active surveillance or surgery and patients with metastatic renal cell carcinoma undergo follow up pMRI at 1-6 months. After completion of study, patients are followed up within 48 hours.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
75
Undergo arterial spin labeled perfusion magnetic resonance imaging
Undergo dynamic contrast-enhanced perfusion magnetic resonance imaging
Undergo dynamic susceptibility contrast-enhanced perfusion magnetic resonance imaging
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States
Perfusion MRI outputs
Univariate and multivariate analyses will be performed to look for associations between pMRI outputs and tumor histopathology. The utilization of perfusion MRI as a diagnostic biomarker for tumor grade and histological subtype will be assessed by correlative comparison to histological evaluation by pathology.
Time frame: Up to 6 months
Progression free survival
Kaplan-Meier survival curves will be performed to compare groups of patients to assess progression-free survival.
Time frame: Up to 6 months
Sensitivity of pMRI
If possible, receiver operating characteristic curves will be created from pMRI data.
Time frame: Up to 6 months
Specificity of pMRI
If possible, receiver operating characteristic curves will be created from pMRI data.
Time frame: Up to 6 months
Tumor histopathology
Univariate and multivariate analyses will be performed to look for associations between pMRI outputs and tumor histopathology. The utilization of perfusion MRI as a diagnostic biomarker for tumor grade and histological subtype will be assessed by correlative comparison to histological evaluation by pathology.
Time frame: Up to 6 months
Progression free survival and/or radiographic tumor evaluation
The utility of pMRI as a therapeutic biomarker for monitoring or predicting treatment response will be assessed by correlative comparison to progression free survival and/or radiographic tumor evaluation by standard of care radiologic imaging modality, such as Response Evaluation Criteria in Solid Tumors.
Time frame: Up to 6 months
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Undergo perfusion magnetic resonance imaging