Safety and Immunogenicity Study of Live Attenuated Vaccine Against Herpes Zoster in Chinese Adults Aged 50 Years and Older

Inclusion Criteria: * Adults 50 years and older,no vaccine contraindications; * Subject to comply with the requirements of clinical trial programs; * No immune globulin vaccination history within a month, no vaccination history within 28 days; * Axillary temperature ≤37.0 ℃; * Patients with chronic diseases should be in stable ; * Postmenopausal or female subjects is no longer the possibility of pregnancy, or subjects pregnancy test was negative and has no pregnancy planner during the clinical trial period; * The value of blood routine (WBC, RBC, Hb) is normal , or abnormal but meaningless by clinicians judgment ; * Alanine aminotransferase (ALT) values is normal, or abnormal but meaningless by clinicians judgment ; * Renal function (serum urea nitrogen) is normal, or abnormal but meaningless by clinicians judgment. Exclusion Criteria: * Allergies, seizures, epilepsy, encephalopathy and other medical history or family history of mental illness; * Subjects who is allergic to any element of the vaccine,and have a history of severe allergy to any vaccine; * Subjects who is suffering from immune deficiency, receiving immunosuppressive therapy or immunocompromised due to HIV; * Subjects who had a history of herpes zoster five years ago; * Varicella or herpes zoster vaccination history; * Pregnant or lactating women; * Women who are planning a pregnancy in the near future; * Any prior administration of vaccine in last 28 days or planned to vaccinate any vaccine during the observation period; * Suffering from acute febrile diseases, and infectious diseases; * Thrombocytopenia or other coagulation disorder history, which may cause subcutaneous taboo; * Accept any other investigational drug users within two months; * Subjects had high fever (axillary temperature ≥38.0 ℃) in the past three days ; * The value of blood routine (WBC, RBC, Hb) is abnormal and meaning by clinicians judgment ; * Alanine aminotransferase (ALT) values is abnormal and meaning by clinicians judgment ; * Renal function (serum urea nitrogen) is abnormal and meaning by clinicians judgment. * Blood pressure is abnormal after medication control; * Known or suspected diseases including: respiratory diseases, acute infection or chronic disease , and cardiovascular disease, kidney disease, skin disorders in the acute phase; * Any condition that in the opinion of the investigator, may interfere with the evaluation of study objectives.