Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain

VA Pittsburgh Healthcare System10 enrolled

Overview

Research suggests that the type of anesthesia used for surgery may affect intraoperative stress hormone levels. There is also data to support that an increased level of stress hormones leads to increased pain after surgery. The primary aim of this study is to determine the effect of anesthesia type on long term pain after hernia surgery. In this study, patients undergoing inguinal hernia repair will be randomized to an anesthetic group, either Total Intravenous Anesthesia (TIVA) maintained with propofol or Balanced Inhaled Anesthesia (BIA) maintained with sevoflurane. This will allow us to look at any differences in short and long-term pain after hernia repair depending on type of anesthesia received.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Acute Pain Chronic Pain Hernia Anesthesia, Intravenous

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All male patients undergoing herniorrhaphy surgery that requires general anesthesia. Exclusion Criteria: * Subjects unable to communicate directly with the investigators, due to being non-English speaking, loss of hearing, or incompetence. * A history of malignant hyperthermia, pseudocholinesterase deficiency, or other disease that prevents anesthetic randomization. * Pain-related disorders such as fibromyalgia or other chronic pain syndromes. * Emergency surgery.

Outcomes

Primary Outcomes

Pain Score, Chronic

Pain as measured by the Intensity Score of the Pain Quality Assessment Scale (PQAS) at each of the time points after surgery. The scale goes from 0 (no pain) to 10 (the most intense pain sensation imaginable). Higher scores mean worse pain.

Time frame: 1 month, 3 months, 6 months, 12 months

Secondary Outcomes

Pain Score, Acute

Acute Pain on Day 1, as measured by the Pain Quality Assessment Scale (PQAS). The scale goes from 0 (no pain) to 10 (the most intense pain sensation imaginable). Higher scores means worse pain.

Time frame: 1 day