Biological Stardadization of D. Pteronyssinus and D. Farinae Allergen Extracts

Inclusion Criteria: * Clinical history positive inhalation allergy (rhinitis I rhinoconjunctivitis I asthma) against Dermatophagoides pteronyssinus or Dermatophagoides farinae. * A prick-test positive (average of the papule ≥ 3 mm diameter) with a summary of the same allergen I presence against the allergen specific Immunoglobulin E. * The average area of the papule obtained by histamine dihydrochloride to 10 mgml must be greater than or equal 7 mm2. * Age: over 18 years of age. * Both sexes. Exclusion Criteria: * Subjects outside of the age range. * Individuals who have previously received immunotherapy in the last 5 years for the treatment of asthma or the allergic rhinoconjunctivitis induced by allergens that may interfere with the extract mixture of Dermatophagoides pteronyssinus or farinae. * Subjects with important symptoms of rhinoconjunctivitis I bronchial asthma in which the suspension of the antihistamine treatment for systemic is contraindicated. * Subjects that have previously submitted a serious secondary reaction during skin prick test diagnostic tests. * Subjects in treatment with ss-blockers. * Unstable subjects of clinical point of view (asthma acute, febrile, etc.). * Subjects with lesions of active hives, severe active dermographism, severe atopic dermatitis, sunburn, eczema, lesions of psoriasis in the area of realization of the prick test (risk of false positives). * Subjects with viral infection activates the herpes simplex or herpes varicella-zoster in the area of realization of the prick test. * Subjects that have some pathology in which the administration of adrenaline (hyperthyroidism, hypertension, heart disease, etc.) is contraindicated. * States of the subject that can not offer cooperation and severe psychiatric disorders. * Pregnant or women at risk of pregnancy and breastfeeding women.