Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection

* INCLUSION CRITERIA * Age 18-61 years old * Laboratory-confirmed HIV-1 infection * CD4 count \>350 cells/mm\^3 * Plasma HIV RNA \<50 copies/mL for at least 12 months prior to screening. Participants who have a viral blip of up to 200 copies/mL may be included if they have a preceding and following VL \<50 copies/mL. * Stable antiretroviral therapy regimen for greater than or equal to 3 months prior to screening * Weight greater than or equal to 50 kg * Have participated in NIH protocol 13 N-0149 or the JHU Clinical Outcomes Core * Completion of at least 7th grade (according to subject report) and ability to speak, read, and understand English to allow use of standard neurocognitive batteries * An established primary care provider * Willingness to have blood and CSF samples stored for future research * Willingness to undergo serial lumbar punctures (LPs) per study schedule * Willingness to undergo genetic testing * For women of childbearing potential, willingness to use 2 forms of effective birth control beginning 2 weeks before and continuing until 12 weeks after the start of anakinra. One method must be a condom and the other may be a diaphragm or cervical cap with spermicide, oral contraceptive, implant, contraceptive patch, IUD placed at least 3 months ago or having a male partner who had a vasectomy at least 3 months ago. EXCLUSION CRITERIA * Presence of a neurologic condition that would confound study evaluations (eg, multiple sclerosis, Parkinson s disease). Neurologic conditions that would not interfere with study evaluations (eg, migraine, peripheral neuropathy) will be allowed. * Presence of a condition, other than HAND, associated with cognitive impairment (e.g. untreated severe sleep apnea) at screening * Presence of HIV-associated dementia as determined through participation in NIH protocol 13-N-0149 or the JHU Clinical Outcomes Core * Inability to provide informed consent * Past or current psychiatric illness that may interfere with protocol adherence (eg schizophrenia or bipolar disorder) * Use of any psychiatric medications unless stable greater than or equal to 3 months at the time of screening * Current asthma requiring treatment * History of any AIDS-defining opportunistic infection in the past two years or any history of a CNS opportunistic infection * History of lymphoma or melanoma * Any medical condition (eg, congestive heart failure, coronary artery disease, chronic obstructive pulmonary disease, severe osteoarthritis) that would make frequent study visits and travel difficult for the participant * Positive urine drug screen or active abuse of illegal drugs, narcotics or alcohol as determined by the study investigator at the time of screening or at baseline evaluations * Women who are pregnant or actively seeking to become pregnant * Women who are breastfeeding * Use of any systemic immunosuppressive medication, including TNF inhibitors, within five half lives of the drug prior to of screening * Contraindications to LP including: International Normalized Ratio (INR) \>1.5, platelets \<100,000/Microlitre, or inability to temporarily discontinue aspirin for 7-10 days and nonsteroidal anti-inflammatory drugs for 3 days prior to LP * Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \>2.5x laboratory upper limit of normal * Absolute neutrophil count \<1000/mm\^3 or hemoglobin \<10mg/dL * Estimated glomerular filtration rate \<60 mL/min or a history of renal dialysis * Other laboratory abnormality that would make the study risky for the patient as determined by the study investigator * Acute or chronic hepatitis C virus infection determined by a detectable VL * Acute or chronic hepatitis B determined by detectable hepatitis B surface antigen (HbsAg) or hepatitis B core antibody (HbcAb) IgM * History of tuberculosis (TB), or positive TB test at screening (QuantiFERON or tuberculin skin test) * Other infection (eg, influenza, urinary tract infection) that would affect response to anakinra, or that would represent a risk of significant infection based upon the known effects of anakinra, and the likely effects of anakinra on this population. * Receipt of live vaccine within four weeks of starting anakinra or planned within three months after study completion * Contraindication to MRI including pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, some types of aneurysm clips (metal clips on the wall of a large artery), some types of metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, or shrapnel fragments. Participants who require sedation for claustrophobia during the MRI will not be excluded. * Known hypersensitivity or contraindication to gadolinium or any component of anakinra * Participation in a clinical protocol (e.g. anti-inflammatory drug intervention study) which includes an intervention that may affect the results of the current study. * Any condition that would increase risk to the subject or would interfere with the subject s ability to comply with protocol requirements (e.g. inability to travel to the study site frequently).