This study will evaluate the safety of povidone-iodine irrigation in pediatric spinal patients by collecting pre- and post-operative safety labwork. Furthermore, the efficacy of povidone-iodine and normal saline irrigation at reducing bacterial contamination of the surgical wound will be measured by collecting cultures before and after irrigation.
Previous research has shown there is baseline bacterial contamination of surgical spinal wounds prior to closure. While this bacterial contamination may or may not lead to infection, recent adult studies demonstrated reduced infection rates by using povidone-iodine irrigation before closure. This study will determine the safety of using povidone-iodine irrigation in pediatric spinal patients and how effective it is at reducing bacterial contamination of the spinal surgical wound prior to closure, compared with normal saline. The investigators hypothesize povidone-iodine is both safe and effective. Understanding techniques that reduce the local bacterial load in the wound prior to closure after spinal fusion will give data to support measures that will ultimately reduce the rate of postoperative infections.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
173
Chemical complex of polyvinylpyrrolidone (povidone, PVP) and elemental iodine
Solution of 0.90% w/v of NaCl, 308 mOsm/L or 9.0 g per liter
Children's Mercy Kansas City
Kansas City, Missouri, United States
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Culture Positivity
Assess feasibility of a larger randomized controlled trial using significance of differences in the bacteriology and contamination rates of both treatment arms. Also measured baseline tissue colonization rates.
Time frame: Cultures taken before and after irrigation during surgery
Risk Groups
Baseline (pre-irrigation) and post-irrigation tissue colonization rates and changes in culture positivity
Time frame: Cultures taken before and after irrigation during surgery
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