Identification of Volatile Organic Compounds in Exhaled Air During Exacerbation of Chronic Obstructive Pulmonary Disease

Centre Hospitalier Universitaire de Saint Etienne19 enrolled

Overview

Exacerbations of the disease are a hallmark of Chronic Obstructive Pulmonary Disease (COPD), affecting the decline of pulmonary function, quality of life and increasing morbidity. The use of validated biomarkers could help to identify the etiology of exacerbation and to prescribe antibiotherapy when indicated. The analysis of exhaled air allows measuring different volatile organic compounds (VOC) which reflect local or systemic inflammation and oxidative stress. The relationship between the presence of some of these compounds and the exacerbation of COPD has never been studied. The aim of this study is to identify a cluster of VOC in COPD patients during an acute exacerbation of the disease, compared to a stable condition (3 months after discharge). Investigators also will seek for a relationship between VOC and the etiology of exacerbation (bacterial, viral, inflammatory).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Measurement of VOC in exhaled airOTHER

Measurement of VOC in exhaled air during 10 min (tidal breathing) with a portable mass spectrometer

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria of COPD group: * COPD stages 2 and 3 of GOLD score (30 ≤ forced expiratory volume at one second (FEV1) \< 80% of predicted value), * exacerbation confirmed clinically (increased dyspnea, cough or expectorations \> 48 hours) Inclusion Criteria of non COPD group: * No smoker (\<100 cigarettes/year) Exclusion Criteria of COPD group: * Diagnosis of COPD not confirmed. * Instable clinical status with respiratory failure and indication of mechanical ventilation. * Bronchodilator treatment changed * Antibiotic treatment started in the 10 last days before admission Exclusion Criteria of non COPD group: * Chronic inflammatory disease * Any respiratory disease * Oral corticosteroid treatment during the last month

Outcomes

Primary Outcomes

Spectrum of VOC measured with a portable mass spectrometer system

Spectrum of VOC in exhaled air in patients with COPD compared to those of control subjects. It is measured with a portable mass spectrometer system.

Time frame: Day 1 (within 48 hours after hospital admission for exacerbation of COPD)

Secondary Outcomes

Variation in VOC spectrum in COPD patients measured with a portable mass spectrometer system

Variation in VOC spectrum in COPD patients during exacerbation and in stable condition (3 months later). It is measured with a portable mass spectrometer system.

Time frame: 3 months after hospital discharge