Non-invasive Evaluation of Portal Pressure by MRI

University Hospital, Toulouse100 enrolled

Overview

The objective of this research is to study the correlation between the portosystemic pressure gradient and azygos blood flow measured by MRI.

All patients will benefit from: * Pressure gradient measurement portosystemic * MRI measurement of azygos flow, aortic, portals, spleen and lower cellar * Liver biopsy * Laboratory tests

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

Chronic Liver Disease

Interventions

InterventionPROCEDURE

All patients performing the biopsy will have an MRI to carry out the necessary measures.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Suspicion of chronic liver disease * Indication to perform a liver biopsy transjugular * Patient able to consent Exclusion Criteria: * contraindication to MRI: * Holders of a pacemaker or a defibrillator, an implanted material activated by electrical, magnetic or mechanical * Holders of hemostatic clips intracerebral aneurysms or carotid arteries, bearing orthopedic implants * claustrophobic * Severe hepatic encephalopathy * Inability to MRI in the week surrounding the first jugular

Locations (1)

UH Toulouse

Toulouse, France

Outcomes

Primary Outcomes

Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and azygos flow measured by MRI.

MRI and catheterization will be performed the same week. For the azygos blood flow (by MRI), measures will be repeated 5 times. Speed of extraction and the rate on the post processing console will be made with a double reading. For the measurement of portal pressure by catheterization, will be performed measurements of occluded hepatic vein pressure and free hepatic vein. They will be repeated 3 times each. These measures will be carried out to calculate the portosystemic pressure gradient. The flow rate and gradient measurements will be performed blindly to the other.

Time frame: 1 week

Secondary Outcomes

Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and aortic flow measured by MRI.

This outcome is different of primary outcome because the Measurement of azygos blood flow (MRI) is repeated on a strictly perpendicular section to the vessel facing the T4-T5 disk and the extraction speed rate and on post processing console is made by double reading. Measuring portal pressure by catheterization. Measurements of occluded hepatic vein pressure and free hepatic vein and will be repeated 3 times each. Flow measurements and gradient will be carried out blind to each other by the radiologist and the hepatologist.

Time frame: 1 week

Correlation between portosystemic pressure gradient measured by catheterization of the hepatic veins transjugular and throughput inferior vena measured by MRI.

Measurement of azygos blood flow (MRI) Repeated Measure 5 times on a strictly perpendicular cut to the vessel immediately after anastomosis of the hepatic veins to the inferior vena cava and Extraction speed and flow on post processing console with double reading. Measurement of portal pressure by catheterization It will be defined by the measures of occluded hepatic vein pressure and free hepatic vein and measurements will be repeated 3 times each. The flow rate and gradient measurements will be performed blindly to the other.

Data from ClinicalTrials.gov

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