Energy Expenditure of People Living With HIV/AIDS

University of Sao Paulo General Hospital45 enrolled

Overview

Background: Several studies have reported increased resting energy expenditure (REE) in people living with HIV/AIDS possibly due to changes in body composition that occurs in HIV lipodystrophy syndrome. The aim of this study was to evaluate the influence of the use of lipid-lowering drugs in resting energy expenditure (REE) and total energy expenditure (TEE) in patients seropositive for HIV in treatment of lipodystrophy.

REE was measured by indirect calorimetry. TEE was measured by doubly labeled water (DLW) technique and an activity monitor based on accelerometry (AM).

Study Type

OBSERVATIONAL

Enrollment

Conditions

HIV/AIDS HIV Lipodystrophy Syndrome

Interventions

use of lipid-lowering drugs.DRUG

The patients shoud be in use of a lipid-lowering drugs previouly, at least one month before of the begining of the study.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Use of antiretroviral therapy for at least 4 months * A cluster of differentiation 4 (CD4) T-cell count of \>200 cells/mm3 * Use of lipid-lowering drugs for at least 1 month (group HIV-seropositive with lipodystrophy and use of lipid-lowering) Exclusion Criteria: * Signs or symptoms of opportunistic infections * Thyroid disease

Outcomes

Primary Outcomes

Total Energy Expenditure (kcal/d)

Time frame: 14 day

Resting Energy Expenditure (kcal/d)

Time frame: 1 day

Secondary Outcomes

Correlation between doubly labeled water and accelerometer to measure total energy expenditure (ICC, 95% CI)

Time frame: 14 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.