Study of DS-7080a for the Treatment of Macular Degeneration

Inclusion Criteria: For parts 1 and 2: * ≥ 50 years of age * Has active primary subfoveal choroid neovascularization (CNV) lesions secondary to age-related macular degeneration (AMD) * CNV ≥ 50% of total lesion size in study eye * Central sub-field thickness \> 315 µm on spectral domain optical coherence tomography (SD-OCT) in the study eye * Has BCVA letter score required at screening visit: * For Part 1, ≤ 49 (approximately 20/100 or worse) in the study eye and ≥ 49 (approximately 20/100 or better) in the fellow eye * For Part 2, 78 to 25 (approximately 20/32 to 20/320) in the study eye For Part 3: * Is ≥ 18 years of age with retinal thickening due to diabetic macular edema (DME) * Has central sub-field thickness (CST) \> 335 μm in the study eye * Has BCVA letter score at screening visit 78 to 25 letters (approximately 20/32 to 20/320) in the study eye Exclusion Criteria: For Parts 1 and 2: * Has used any long acting steroids, either systemically or intraocularly, within 6 months of Baseline Visit * Has total lesion size \> 12 disc areas (30.5 mm2) in the study eye * Has presence of retinal pigment epithelial tears or rips involving the macula in the study eye * Has history of any vitreous hemorrhage within 4 weeks prior to Screening Visit in the study eye * Has presence of causes of CNV other than AMD * Had prior vitrectomy in the study eye * Has history of retinal detachment or treatment or surgery for retinal detachment in the study eye * Has any history of a full thickness macular hole in the study eye * Had any intraocular or periocular surgery within 3 months of Baseline Visit on the study eye, except lid surgery * Has uncontrolled glaucoma in the study eye * Has active intraocular inflammation or periocular infection in either eye * Has any history of uveitis in either eye of scleromalacia in either eye * Has aphakia or pseudophakia in the study eye * Had previous therapeutic radiation in the region of the study eye * Has history of corneal transplant or corneal dystrophy in the study eye * Has significant media opacities in the study eye (e.g. cataract) that could require either medical or surgical intervention during the study period * Is a women who is pregnant, breastfeeding, or of childbearing potential and unwilling to practice two measures of adequate contraception throughout the study For Part 1 only: * Had any ocular (in the study eye) or systemic treatment or surgery for neovascular AMD within 4 weeks of Baseline Visit, except dietary supplements or vitamins * Has a subretinal hemorrhage that is ≥ 50% of the total lesion area in the study eye * Has scarring or fibrosis, making up \>50% of total lesion or involving the center of the fovea in the study eye For Part 2 only: * Had any prior therapy in the study eye within 3 months of Baseline Visit, except dietary supplements or vitamins For Part 3: * Has used any steroids, either systemically or ocular in the study eye (other than fluocinolone), within 6 months of Baseline Visit * Has macular edema in the study eye considered to be due to a cause other than DME * Has high-risk proliferative diabetic retinopathy (PDR) in the study eye * Has decrease in BCVA in the study eye due to causes other than DME * Has significant macular ischemia in the study * Has choroidal neovascularization (CNV) secondary to any etiology * Has retinal pigment epithelial tears or rips involving the macula in the study eye * Had any vitreous hemorrhage within 4 weeks prior to Screening/Visit 1 in the study eye * Had prior vitrectomy in the study eye * Has history of retinal detachment or treatment or surgery for retinal detachment in the study eye * Has history of a full thickness macular hole in the study eye * Had any intraocular or periocular surgery within 3 months of Baseline Visit * Has uncontrolled glaucoma in the study eye * Had prior trabeculectomy or other filtration surgery in the study eye * Has active intraocular inflammation or periocular infection in either eye * Has current or history of scleromalacia in either eye * Has aphakia or pseudophakia with absence of posterior capsule * Has previous therapeutic radiation in the region of the study eye * Has history of corneal transplant or corneal dystrophy in the study eye * Has concurrent ocular condition in the study eye which, in the opinion of the investigator, could either increase the risk to the subject beyond what is to be expected from standard procedures of intraocular injection, or which otherwise may interfere with the injection procedure or with evaluation of safety, tolerability, or efficacy * Has systolic blood pressure ≥160 mmHg and/or a diastolic blood pressure ≥95 mmHg at Screening * Has an estimated Glomerular Filtration Rate (eGFR) of \< 15 mL/min/1.73 m\^2 as per the creatinine equation (CKD-EPI) at Screening * Has any history of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that might affect interpretation of the results of the study or render the subject at high risk for treatment complications * Is a women who is pregnant, breastfeeding, or of childbearing potential and unwilling to practice two measures of adequate contraception throughout the study