Systemic Sclerosis Clinical and Biomarker Study

Key Inclusion Criteria: Healthy volunteers * Must be in good health as determined by the Investigator, based on medical history, physical examination, and vital signs. Participants with diffuse cutaneous systemic sclerosis (dcSSc): * Must fulfill the 2013 classification criteria for SSc of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR). * Absence of the anti-centromere autoantibody. Participants with limited cutaneous systemic sclerosis (lcSSc): * Must fulfill the 2013 classification criteria for SSc of the ACR and EULAR. * Subjects with lcSSc must have disease duration of less than 5 years. Key Exclusion Criteria: * History of any clinically significant medical condition that can interfere with the conduct of the study, or that in the opinion of the Investigator, would compromise data interpretation. * An active severe infection as determined by the Investigator. * Female subjects who are pregnant or currently breastfeeding. * A known history of malignancy. NOTE: Other protocol defined Inclusion/Exclusion criteria may apply