Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly.
Different neurological damage may alter the pain conduction systems centrally (spinothalamic pathway) or peripherally (small caliber sensory fibers A delta and C). The laser thermal stimulation selectively stimulates the pain pathways and generates nociceptive signals conveyed to the cortex. Registering these cortical responses constitute the technical laser nociceptive evoked potentials. If these tests are routinely used, their interpretation must remain cautious especially in the elderly. Normal values that are available have been obtained in young subjects. However, various studies have shown that the integration of nociceptive messages depended on age. The aim of this study was to establish normal values of nociceptive evoked potentials for each age group of 18 to 75 years.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
120
20 laser stimulations for each site : back foot, outer face of the legs, and anterior thigh
15 laser stimulations cervical areas below the ears.
20 laser stimulations for each site : back of the hands and arms front face
Chu de Saint Etienne
Saint-Etienne, France
composite outcomes : latencies (ms) and amplitudes (μV) of nociceptive evoked potential
Time frame: Day 0
detection threshold (mJ/mm2)
Time frame: Day 0
nociceptive threshold (mJ/mm2)
Time frame: day 0
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15 lasers stimulations for each site : mandibular areas and areas below the ears.