The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults

Karolinska Institutet34 enrolled

Overview

In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions). Before and after training, muscle volume is measured by MRI, and muscle strength is assessed by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus lateralis to study gene and protein expression of markers regulating muscle protein turnover and prostaglandin synthesis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Skeletal Muscle Mass Regulation

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Considered healthy * Moderately trained * 18-35 yrs Exclusion Criteria: * Cardiovascular disease * Impaired kidney or liver function * Lower limb injury * Pregnancy * Ulcer or gastrointestinal upsets * Previous reactions to use of NSAID

Outcomes

Primary Outcomes

Change in Quadriceps muscle volume

Measured through MRI

Time frame: Baseline and after 8 weeks training

Secondary Outcomes

Change in muscle gene expression

Through quantitative PCR and microarray

Time frame: Baseline, 4 weeks and after 8 weeks training

Change in muscle protein expression

Through Western Blots