The Efficiency of MSC in Refractory Crohn's Disease

Inclusion Criteria: * Failure or intolerance to GC, immune inhibitors and biological agents treatment * CDAI between 250-450 * Weight between 40-150 kg * Normal renal function * endoscopic or imaging diagnosis of CD in the small intestine, colon ileocolon * Signed informed consent Exclusion Criteria: * HIV or active hepatitis patients; * Allergic to CT contrast agents, cattle or pig products; * Stricture or perforation type CD; * Recieved permanent colostomy; * Used biological preparation in 3 months * Used prednisone \> 20 mg/day within 1 month ; * Patients with short bowel syndrome; * Need total parenteral nutrition; * Liver meritorious service is abnormal; * Suffering from malignant tumor during the last 5 years; * Combined bacterial or viral enteritis; * Suffering from intestinal typicality thickening of the living * Patients with tuberculosis.