The presence of Obstructive Sleep Apnea Syndrome (OSAS) has a high frequency in patients victims of a coronary artery disease (CAD) (myocardial infarction, revascularization). Unlike patients seen in a sleep Laboratory with an impact on daytime functioning, CAD apneic patients do not complain in their daytime functioning. The objective of this study is to explore whether the objective cognitive assessment measures may be a good marker of the efficacy of CPAP treatment given to non-sleepy apneic CAD patients. Coronary patients with an AHI between 15 and 40 / h will be treated (or not) after randomization with CPAP treatment. The expected results are: CPAP apneic coronary patients should have a positive impact on cognitive performance, particularly on attention span and working memory measured by improvement in the Paced Auditory Serial Addition Test score (PASAT score).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
9
Patients treated wear a face mask during sleep which is connected to a pump (CPAP machine) that forces air into the nasal passages at pressures high enough to overcome obstructions in the airway and stimulate normal breathing.
CHU de SAINT-ETIENNE
Saint-Etienne, France
PASAT-4sec test score
The PASAT is a measure of cognitive function that assesses auditory information processing speed and flexibility, as well as calculation ability. Single digits are presented every 4 seconds and the patient must add each new digit to the one immediately prior to it. The score for the PASAT is the total number correct out of 60 possible answers.
Time frame: Day 120
Score Mini Mental State (MMS)
It is a score obtained in psychometric tests. This is a series of 30 questions that assesses cognitive and mnemonic ability of a person.
Time frame: Day 120
Mean time (ms) obtained in a Continus Performance Test
It is an other score obtained in psychometric tests. It measures a person's sustained and selective attention (associated with impulsivity and distractibility).
Time frame: Day 120
Percentage (%) obtained in a test measurement of the reaction time
It is an other score obtained in psychometric tests. It is a psychometer vigilance test.
Time frame: Day 120
Mean time (ms) obtained in a test measurement of the reaction time
It is an other score obtained in psychometric tests. It is a psychometer vigilance test.
Time frame: Day 120
Percentage (%) for a N-back working memory task
It is an other score obtained in psychometric tests. The subject is presented with a sequence of stimuli, and the task consists of indicating when the current stimulus matches the one from n steps earlier in the sequence.
Time frame: Day 120
Average time (ms) for a N-back working memory task
It is an other score obtained in psychometric tests. The subject is presented with a sequence of stimuli, and the task consists of indicating when the current stimulus matches the one from n steps earlier in the sequence.
Time frame: Day 120
AHI
It is the number of apnea and hypopnea per hour. It determined by polysomnography.
Time frame: Day 120
Mean nocturnal oxygen saturation (%)
It is a percentage index of hypoxemia measured by a polysomnography.
Time frame: Day 120
Minimal nocturnal oxygen saturation (%)
It is an other percentage index of hypoxemia measured by a polysomnography.
Time frame: Day 120
The oxyhemoglobin desaturation index
It is an other index of hypoxemia measured by a polysomnography. It is expressed in desaturations / hour
Time frame: Day 120
The time (min) spent with a SaO2 below 90%
The arterial oxygen saturation (SaO2)is an other index of hypoxemia measured by a polysomnography.
Time frame: Day 120
Sleep fragmentation
It is determined by a polysomnography.
Time frame: Day 120
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