In this study, it is aimed to evaluate whether use of a ureteral access sheath (UAS) during retrograde intrarenal surgery (RIRS) due to kidney stone has any effect on protecting the kidney functions by measuring blood and urine and Netrin-1 levels.
This study will include patients aged between 18 and 65 who will undergo retrograde intrarenal surgery (RIRS) due to renal stone(s). A total of 60 patients (male or female) will be recruited, and will be randomized into 2 groups consisting of 30 patients in each group. The first group of patients will undergo RIRS with a ureteral access sheath (UAS) positioned prior to surgery; and the second group will undergo RIRS without UAS. As use of UAS decreases the pressure in the renal pelvis during RIRS, it is aimed to evaluate whether using UAS or not affects the kidney functions. Besides the routine kidney function tests, namely urea and creatinine, and Netrin-1 (more specific and early marker of kidney function) will be used to assess the differences in the kidney functions. Preoperative blood urea, creatinine and Netrin-1 levels and urine Netrin-1 levels will be studied for all patients. After the surgery, blood urea and creatinine levels will be again studied as well as blood Netrin-1 levels at postoperative 48th hour; and urine Netrin-1 levels at postoperative 24th hour.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Ureteral access sheath (UAS) will be used during RIRS.
Ureteral access sheath will not be used during RIRS.
Selcuk University, School of Medicine, Department of Urology
Konya, Turkey (Türkiye)
RECRUITINGBlood Netrin-1 level (pg/mL)
Determination of any impairment in renal function when ureteral access sheath is not used during RIRS by measuring blood Netrin-1 level.
Time frame: Within the first 48 hours after the surgery (RIRS)
Urine Netrin-1 level (pg/mL)
Determination of any impairment in renal function when ureteral access sheath is not used during RIRS by measuring urine Netrin-1 level.
Time frame: Within the first 24 hours after the surgery (RIRS)
Blood urea level (mg/dL)
Determination of any impairment in renal function when ureteral access sheath is not used during RIRS by measuring blood urea levels.
Time frame: Within the first 7 days after surgery (RIRS)
Blood creatinine level (mg/dL)
Determination of any impairment in renal function when ureteral access sheath is not used during RIRS by measuring blood creatinine levels.
Time frame: Within the first 7 days after surgery (RIRS)
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