ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization

Abington Memorial Hospital25 enrolled

Overview

A prospective pilot study to evaluate the recanalization and safety of mechanical thrombectomy through a cerebral angiogram in patients with stroke symptoms last seen normal between 8 - 24 hours.

Ischemic stroke patients who are 8-24 hrs from symptom onset without prior mechanical or IV thrombolytic treatment and are screen with CT or MR perfusion imaging showing penumbra and infarction not \> 1/3rd the territory.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Ischemic Stroke

Interventions

mechanical thrombectomyDEVICE

Mechanical thrombectomy by either Penumbra system, TREVO, or Solitaire retrieval device

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Over 18 years last seen normal between 8 - 24 hours, without prior history of intravenous plasminogen activator (IV t-PA ) or * mechanical thrombectomy Vessels - intracranial vertebral artery, basilar artery, intracranial ICA, ICA terminus bifurcation, MCA M1/M2, or * ACA NIHSS ≥ 7 MRI DWI/PWI or * CTA/P, which demonstrates an area of mismatch ≥ 2/3 rd * Signed informed consent Exclusion Criteria: * creat \>= 2 * NIHSS \< 7 * Baseline mRS \>= 2 * infarct \> 1/3rd MCA territory * competing trials * prior IV or IA treatment

Locations (1)

Abington Memorial Hospital

Abington, Pennsylvania, United States

Outcomes

Primary Outcomes

Thrombolysis in Cerebral Infarction (TICI) score

Time frame: 6 months

Secondary Outcomes

National Institutes of Health Stroke Scale (NIHSS) score

Time frame: 6 months

Montreal Cognitive Assessment (MoCA) tool

Time frame: 6 months

Modified Rankin Scale

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.