Study of the Interactions Between Dientamoba Fragilis and the Gut Microbiota

University Hospital, Strasbourg, France27 enrolled

Overview

D.fragilis is an intestinal protozoon that feeds by phagocytosis of intestinal bacteria. The study aim to determine if the carriage of the intestinal parasite D.fragilis is associated to changes of gut microbiota in subjects presenting with or without intestinal symptoms.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Diarrhea

Interventions

Stool sampling and sequencing of gut microbiota.OTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for symptomatic group: * male/female aged at least of 18 years * subject with abdominal pain, diarrhea, bloating * no other known intestinal disease Inclusion Criteria for asymptomatic group: * male/female aged at least of 18 years * no known intestinal disease Exclusion Criteria of symptomatic and asymptomatic groups: * chronic intestinal diseases such as IBD, IBS … * intake of antibiotic or probiotic within the 2 last months * subject in exclusion period * subject unable to understand information for a free consent to the study * subject in safeguarding justice or guardianship

Locations (4)

Laboratoire de Parasitologie et de Mycologie Médicale du Plateau Technique de Microbiologie des Hôpitaux Universitaires de Strasbourg

Strasbourg, France

Médecine interne, maladies tropicales et infectieuses Hôpital Civil

Strasbourg, France

Service de Médecine Interne - Diabète et Maladies métaboliques Hôpital Civil

Strasbourg, France

Service d'hépato gastro-entérologie et assistance nutritive Hôpital Hautepierre

Strasbourg, France

Outcomes

Primary Outcomes

16SrRNA copy numbers

Time frame: Within the 2 days following inclusion

Data from ClinicalTrials.gov

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