Effect of Ginger Supplement on Non-alcoholic Fatty Liver

Dr Azita Hekmatdoost60 enrolled

Overview

The hypothesis of this study was that ginger supplement consumption can be introduced as a new therapeutic strategy for non-alcoholic fatty liver disease through the improved body antioxidant activity, reduced levels of inflammation and insulin resistance. A randomized double-blind study was designed to evaluate this hypothesis in order to examine the effectiveness of ginger supplement in patients with non-alcoholic fatty liver disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Non-alcoholic Fatty Liver Disease

Interventions

Ginger supplementDIETARY_SUPPLEMENT

Placebo (starch)DIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * presence of steatosis on ultrasound examination * high concentration of liver enzyme (alanine aminotransferase (ALT) greater than normal range of 1.5 times) Exclusion Criteria: * various types of hepatitis * diabetes mellitus * cancer inherited disorders affecting liver condition (storage disorders of iron, copper, and others) * non-treated hypothyroidism * using alcohol * consumption of phenytoin amoxyfan and lithium * using minerals multivitamin supplements such as vitamin E, vitamin D, supplements made from Silybum marianum extract like livergol * weight loss surgery in the last year or strict diets to weight loss in the past three months pregnancy * lactation * autoimmune diseases

Outcomes

Primary Outcomes

Serum levels of the ALT liver enzyme

Time frame: 12 weeks

Serum levels of the AST liver enzyme

Time frame: 12 weeks

Secondary Outcomes

controlled attenuation parameter(CAP) score

controlled attenuation parameter(CAP) score is a novel measurement for evaluation of hepatic steatosis and it evaluated in dB/m at 3.5 MHz by M probe. normal range is 100- 140 dB/M.

Time frame: 12 weeks

Data from ClinicalTrials.gov

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