Efficacy and Safety of Pyrotinib in Patients With HER2 Mutation Advanced Non-Small Cell Lung Cancer

Inclusion Criteria: * Aged ≥18 and ≤80 years. * ECOG performance status of 0 to 1. * Life expectancy of more than 12 weeks. * At least one measurable lesion exists.(RECIST 1.1) * Histologically or cytologic confirmed HER2 positive advanced Non-small cell lung cancer who failed prior therapies. * Required laboratory values including following parameters: ANC: ≥ 1.5 x 10\^9/L, Platelet count: ≥ 80 x 10\^9/L, Hemoglobin: ≥ 90 g/L, Total bilirubin: ≤ 1.5 x upper limit of normal, ULN, ALT and AST: ≤ 1.5 x ULN, BUN and creatine clearance rate: ≥ 50 mL/min LVEF: ≥ 50% QTcF: \< 470 ms * Signed informed consent. Exclusion Criteria: * Subjects with third space fluid that can not be controled by drainage or other methods. * Subjects that are unable to swallow tablets, or dysfunction of gastrointestinal absorption. * Less than 4 weeks from the last radiotherapy,chemotherapy,target therapy * Subjects with uncontrolled hypokalemia and hypomagnesemia before study entry. * Subjects who can not interrupt the using of the drugs that may cause QT prolongation during study. * Receiving any other antitumor therapy. * Known history of hypersensitivity to pyrotinib or any of it components. Ongoing infection (determined by investigator). * History of immunodeficiency, including HIV-positive, suffering from other acquired, congenital immunodeficiency disease, or history of organ transplantation. * Subjects had any heart disease, including: (1) angina; (2) requiring medication or clinically significant arrhythmia; (3) myocardial infarction; (4) heart failure; (5) Any heart diseases judged by investigator as unsuitable to participate in the trial. * Female patients who are pregnancy, lactation or women who are of childbearing potential tested positive in baseline pregnancy test. * Known history of neurological or psychiatric disease, including epilepsy or dementia.