Consumption of Dairy Yogurt Enhanced Immune Function

Yonsei University120 enrolled

Overview

To investigate the impact of consumption of dairy yogurt with rhamnogalacturonan (RG) in Korean citrus Hallabong peel polysaccharide on Natural Killer (NK) cell activity and circulating cytokine levels.

A randomized, double-blind, placebo-controlled study was conducted on 120 nondiabetic and nonobese subjects. Over an 8 week period, the test group consumed one pack (150ml) of dairy yogurt with 50mg probiotics and 100mg Korean citrus Hallabong peel polysaccharide (60% RG, 20% mono- and di-saccharide, 5% polyphenol) each day, whereas the placebo group consumed the same product without Korean citrus Hallabong peel polysaccharide. NK cell activities (%) were measured based on the ratios of effector cells (E) (peripheral blood mononuclear cell, PBMC) from each participant to Target cell (T) (K562 cells) as 10:1, 5:1, 2.5:1 or 1.25:1.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

120

Conditions

Healthy Volunteers

Interventions

RGDIETARY_SUPPLEMENT

The 100mg Korean citrus Hallabong peel polysaccharide contained 60mg rhamnogalacturonan (RG), 20mg mono- and di-saccharide, 5mg polyphenol, 5mg ash and 10mg moisture

PlaceboDIETARY_SUPPLEMENT

Same product without RG

Eligibility

Sex: ALLMin age: 30 YearsMax age: 69 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The levels of white blood cells under 8x10\^3/μL * males and females * 30-69 years old * nondiabetic and nonobese subjects * able to give informed consent Exclusion Criteria: * consumption of any probiotic products within 1 month before screening * unstable body weight (body-weight change \> 2 kg within 3 months before screening) * diabetes * history/presence of significant metabolic disease * pregnancy or breast-feeding * acute or chronic infection * liver disease, kidney disease, gastrointestinal disease, or any other acute or chronic disease requiring treatment * subjects taking any drugs or supplements

Locations (1)

Yonsei University

Seoul, South Korea

Outcomes

Primary Outcomes

serum cytokine concentrations

Primary outcome will be tested before and after intervention

Time frame: change from baseline in RG at 8 weeks

Data from ClinicalTrials.gov

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