Protein Ingestion and Muscle Carnitine Uptake

University of Nottingham7 enrolled

Overview

The purpose of this study is to assess the effects of a protein-carbohydrate beverage on the absorption of an orally ingested bolus of L-carnitine, compared to flavoured water and carbohydrate-only controls, and to determine whether increasing plasma carnitine availability can impact upon insulin-stimulated muscle carnitine uptake.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Muscle, Skeletal

Interventions

Flavoured waterDIETARY_SUPPLEMENT

Flavoured water + carbohydrateDIETARY_SUPPLEMENT

Flavoured water + carbohydrate + proteinDIETARY_SUPPLEMENT

Eligibility

Sex: MALEMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Body mass index of 18-25 kg/cm2 Exclusion Criteria: * Unhealthy * Smoker * Taking any medication that interferes with skeletal muscle metabolism

Outcomes

Primary Outcomes

Muscle carnitine uptake

Change in forearm carnitine uptake (measured using arterialised-venous - venous balance technique) in response to intervention.

Time frame: 180 minutes

Data from ClinicalTrials.gov

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