Daily Physical Activity After Meals -Long Term Effects on Blood Glucose

Inland Norway University of Applied Sciences40 enrolled

Overview

The postprandial blood glucose concentration is an important risk factor for development of cardiovascular diseases and diabetes. Previous studies have shown that one bout of moderate or light post-meal physical activity effectively blunts the postprandial increase in blood glucose after carbohydrate intake. Pre-meal exercise does not generate such effect. Thus, the effect of exercise on postprandial glycemia depend on the timing of exercise. Even very light physical activity decreases postprandial glycemia when performed in the postprandial period. The purpose of this study was to investigate whether such activity performed each day for 12 weeks would influence blood variables related to glycemic control. METHODS 40 subjects being ethnic Norwegians or of South Asian origin were randomized into an intervention or a control group. They were previously diagnosed as hyperglycemic, or with high risk of type 2 diabetes according to Ramachandran's risc score. Control subjects were told to maintain their usual physical activity patterns during the study period, while the intervention subjects were instructed to undertake a minimum of 30 minutes of daily post-meal physical activity in addition to their usual activity patterns. Venous blood samples were taken before and after the 12 week intervention period. Plasma was analyzed for HbA1c and for fasting and 2hour (OGTT) values of glucose, insulin and c-peptide. The subjects kept a physical activity diary, answered questionnaires and used accelerometers to determine the level of physical activity.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Blood Glucose

Outcomes

Primary Outcomes

Change in Hba1c

Time frame: Pre and post intervention which lasts an average of 12 weeks

Change in Fasted glucose

Time frame: Pre and post intervention which lasts an average of 12 weeks

Change in 2hour glucose

Oral glucose tolerance test (OGTT)

Time frame: Pre and post intervention which lasts an average of 12 weeks

Change in glucose during OGTT

glucose measured by finger sticks every 15. minute during the 2hour oral glucose tolerance test

Time frame: Pre and post intervention which lasts an average of 12 weeks

Change in Physical fitness measured as heart rate during an exercise test

Heart rate measured at the end of 10 minutes ergometer cycle test an given intensity (low) to moderate intensity)

Time frame: Measured pre and post intervention which lasts an average of 12 weeks

Change in Physical fitness measured as oxygen consumption during an exercise test

measured at the end of 10 minutes ergometer cycle test an given intensity (low) by indirect calorimetry

Time frame: Measured pre and post intervention which lasts an average of 12 weeks

Change in Physical fitness measured as respiratory exchange rate during an exercise test

Measured at the end of 10 minutes ergometer cycle test an given intensity (low), by indirect calorimetry

Time frame: Measured pre and post intervention which lasts an average of 12 weeks

Change in Physical fitness measured as perceived exertion during an exercise test

Borg RPE scale measured at the end of 10 minutes ergometer cycle test an given intensity (low)

Time frame: Measured pre and post intervention which lasts an average of 12 weeks

Change in Physical fitness measured as lactic acid during an exercise test

measured at the end of 10 minutes ergometer cycle test an given intensity (low) from capillary blod from a finger stick

Time frame: Measured pre and post intervention which lasts an average of 12 weeks