Crossover randomized controlled double blinded trial : * The primary endpoint is the duration of Non Invasive Ventilation (NIV) session (minutes) with dexmedetomidine (DEX) or placebo. * Secondary endpoints will be the sedation level as assessed by the Richmond Agitation Sedation Scale (RASS), the number of interventions to allow the completion of NIV session, the pain intensity level as assessed by visual analogue scale, the morphine and ketamine consumption during NIV sessions, the comparison of blood gas measurements before and after NIV sessions, the reproducibility of NIV cycles. The side effects of DEX will be notified.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
20
CHU de Grenoble
Grenoble, France
Duration of NIV session
Minutes
Time frame: During ICU stay (expected average of 2 weeks)
Richmond Agitation-Sedation Scale
From -5 (Unarousable) to +4 (Combative)
Time frame: During ICU stay (expected average of 2 weeks)
Number of interventions on NIV settings
Time frame: During ICU stay (expected average of 2 weeks)
Morphine consumption
Morphine administration during NIV session (mg/kg/h)
Time frame: During ICU stay (expected average of 2 weeks)
Ketamine consumption
Ketamine administration during NIV session (mg/kg/h)
Time frame: During ICU stay (expected average of 2 weeks)
Pain visual analogue scale
From 0 (no pain) to 10 (worst pain possible)
Time frame: During ICU stay (expected average of 2 weeks)
Variation of arterial partial pressure of Carbon dioxide (CO2) before and after NIV session
mmHg
Time frame: During ICU stay (expected average of 2 weeks)
Variation of arterial partial pressure of dioxygen (O2) before and after NIV session
mmHg
Time frame: During ICU stay (expected average of 2 weeks)
Variation of potential hydrogen (pH) before and after NIV session
Time frame: During ICU stay (expected average of 2 weeks)
Reproductibility of NIV sessions
Minutes
Time frame: During ICU stay (expected average of 2 weeks)
Bradycardia
Mean arterial pressure less than 55 mmHg
Time frame: During ICU stay (expected average of 2 weeks)
Hypotension
Heart rate less than 40 / mn
Time frame: During ICU stay (expected average of 2 weeks)
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