Spaced phototherapy sessions during winter as add-on therapy in combination with vitamin D supplementation or not, could be beneficial to improve disease LTC in AD patients
The major therapeutic challenge in patient with Atopic Dermatitis is long-term control of disease activity (LTC), for which the current TAT-based pro-active strategy does not meet all the needs. Phototherapy is a good candidate: it is widely used as a second-line treatment in AD with demonstrated efficacy. However, only short-term control has been evaluated; and only 2-3 times a week intensive schedules have been tested and are used in current practice. A novel phototherapy regimen would be required for disease LTC, allowing a trade-off between disease control, UV-induced risks, and patient adherence. Vitamin D supplementation is another good candidate: several studies have shown lower serum levels of vitamin D to be correlated with more severe AD; and three short-term, low-power low-quality, placebo-controlled randomised trials testing vitamin D supplementation yielded conflicting results, leaving its therapeutic efficacy undecided for short-term control, and unknown for LTC.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
111
Hôpital Saint André
Bordeaux, France
Hôpital Morvan
Brest, France
Hôpital Trousseau
Chambray-lès-Tours, France
Centre Hospitalier
Le Mans, France
Hierarchical criterion based on repeated measures of PO-SCORAD severity score
Measurement of PO-SCORAD score
Time frame: 2 years
Hierarchical criterion based on cumulative consumption of topical anti-inflammatory treatments (collected tubes) during winter
Measurement of cumulative consumption of topical anti-inflammatory treatments
Time frame: 2 years
Assessment of desease severity
Assessment of desease severity by EASI score
Time frame: 2 years
Assessment of desease severity
Assessment of desease severity by IGA score
Time frame: 2 years
Assessment of desease severity
Assessment of desease severity by SCORAD score
Time frame: 2 years
Assessment of desease severity
Assessment of desease severity by POEM score
Time frame: 2 years
Assessment of the quality of life
Assessment of the quality of life by DLQI score
Time frame: 2 years
Measurement of serum Vitamin D (25-(OH)-vitamin D)
Time frame: 2 years
Measurement of total IgE serum
Time frame: 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
CHU de Nantes - Hôtel Dieu
Nantes, France
APHP - Hôpital Tenon
Paris, France
Centre Hospitalier
Périgueux, France
Hôpital Laënnec
Quimper, France
Hôpital Pontchaillou
Rennes, France
CHR St Brieuc
Saint-Brieuc, France
...and 1 more locations
Assessement of number of weeks of well-controlled atopic dermatitis
Time frame: 2 years
Assessment of inter-visit cumulative consumption of topical anti-inflammatory treatments
Time frame: 2 years
Assessment of patient satisfaction
Time frame: 2 years