Effect of Varying the Protein and Dietary Fiber Content of Energy Bars on Their Glycemic and Insulinemic Impact

Glycemic Index Laboratories, Inc12 enrolled

Overview

The purpose of this study was to determine the effect of changing the amounts of resistant starch, whey protein and sugar on the blood glucose and insulin responses elicited by energy bars. The investigators also compared the glucose and insulin responses to the rates at which the food bars were digested in-vitro (in the test tube). The investigators thought increasing resistant starch and reducing sugar would reduce the glucose and insulin responses, and that adding protein would reduce glucose and increase insulin. The investigators also thought the glucose and insulin responses in people would be related to the rate of digestion of the food bars in-vitro.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Diabetes Mellitus

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Body mass index 20.0 to 34.9 kg/m² * Fasting serum glucose \<7.0mmol/L * Non-smoker Exclusion Criteria: * Known to have diabetes * Use of medications or presence of a medical condition considered by the principal investigator to increase risk to the participant or affect the results * Known food allergy of any kind

Outcomes

Primary Outcomes

Incremental area under the blood glucose response curve

Time frame: For 3 hours after consuming each test meal

Secondary Outcomes

Incremental area under the serum insulin response curve

Time frame: For 3 hours after consuming each test meal

Incremental area under the blood glucose response curve

Time frame: For 2 hours after consuming each test meal

Incremental area under the serum insulin response curve

Time frame: For 2 hours after consuming each test meal

Insulin:Glucose area under the curve ratio

Outcome 2 (incremental area under the insulin response curve for 3 hours) divided by Outcome 1 (incremental area under the glucose response curve for 3 hours)

Time frame: For 3 hours after consuming each test meal

Insulin:Glucose area under the curve ratio

Outcome 4 (incremental area under the insulin response curve for 2 hours) divided by Outcome 3 (incremental area under the glucose response curve for 2 hours)

Time frame: For 2 hours after consuming each test meal

Insulinogenic index

I30 divided by G30; where I30 is the serum insulin increment at 30 minutes and G30 is the blood glucose increment at 30 minutes; and where "increment" is defined as the concentration at 30 minutes minus the fasting concentration.

Time frame: 30 minutes after consuming each test meal

Effect of Varying the Protein and Dietary Fiber Content of Energy Bars on Their Glycemic and Insulinemic Impact

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes