Longitudinal Cohort Study in Participants With Severe Asthma to Assess Biomarkers

Inclusion Criteria: * Asthma diagnosed by a respiratory physician greater than or equal to (\>/=) 12 months prior to study enrolment * Pre-bronchodilator FEV1 of 30 percent (%) to 85% at baseline/Visit 1 * Documented bronchodilator response defined as \>/=12% relative improvement in FEV1 after bronchodilator administration or a positive methacholine bronchial challenge test with provocative concentration causing a 20% fall in FEV1 (PC20) less than (\<) 8 milligrams (mg) at study baseline/Visit 1 or within 24 months prior to baseline * Current treatment with a total daily dose of \>/= 500 micrograms (mcg) of fluticasone propionate (FP) dry powder inhaler (DPI) (or equivalent ) and at least one of the following controller medications: long-acting Beta-agonist (LABA), leukotriene receptor antagonist (LTRA), long-acting muscarinic antagonists (LAMAs), theophylline or oral corticosteroids, with a continued duration of three months prior to baseline/Visit 1 Exclusion Criteria: * Acute or chronic parasitic, bacterial, fungal or viral infections that required, or currently require, hospitalization or antimicrobial treatment during the last four weeks prior to participant eligibility * Acute asthma exacerbation or any other medical event treated with increased doses of oral, or any dose of intramuscular (IM) or intravenous (IV) corticosteroids within six weeks prior to study * Other relevant pulmonary diseases (e.g. chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension, tuberculosis) requiring treatment within 12 months prior to baseline/Visit 1 * Ex-smokers with \>/=10 pack-year smoking history * Prior treatment with bronchial thermoplasty * Participation in any clinical trial of an investigational agent or procedure within six months prior to baseline/Visit 1 or during the study * Pregnancy prior to participation or during the study