Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma

Lv Yingjuan200 enrolled

Overview

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma. Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Vitamin D Deficiency Primary Open- Angle Glaucoma

Interventions

Vitamin D receptor polymorphic analysisOTHER

Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.

Eligibility

Sex: ALLMin age: 55 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * intraocular pressure greater than 22 mmHg with two or more medications * wide anterior chamber angle * glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) * visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry Exclusion Criteria: * the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma * high myopia * macular degeneration * other ocular diseases * a known history of systemic diseases and administration of vitamin D3 or other analog

Outcomes

Primary Outcomes

Serum levels of 1a, 25-Dihydroxyvitamin D3

Time frame: 1 day visit

Secondary Outcomes

gene polymorphisms of vitamin D receptor