Sleep Study in Adult Patients With Major Sickle Cell Disease With Paroxysmal Nocturnal Events

Inclusion Criteria: Night VOC Group: * night VOC ≥ 2 in the previous year * written informed consent Daytime VOC Group: * VOC no nocturnal * diurnal VOC ≥ 2 in the previous year * written informed consent Slightly symptomatic group: * no hospitalization for VOC * written informed consent Exclusion Criteria: * Taking opioids * Taking medication that alters sleep (antidepressants, benzodiazepines ...) * Known history of sleep apnea syndrome * Known history of serious psychiatric disorder * Recent vaso-occlusive crisis (within 3 weeks) * Changes in background treatment (Hydrea or exchange transfusions) in the past 12 months * Inactive affiliation to social security * Under legal protection * A female who is pregnant or breastfeeding * Prisoners * Emergency situation * Refusing to participate in the study