The Impact of Additional Oral Preparation on the Quality of Bowel Preparation for Colonoscopy

Kyungpook National University Hospital156 enrolled

Overview

Although adequate bowel preparation is essential for successful colonoscopy, the 23% of patients had shown inadequate bowel preparation. Inadequate bowel preparation may results in incomplete examination, increased patient's discomfort, decreased polyp detection rates, ultimately leading to repeated colonoscopies. One prior study showed that patients reporting their last rectal effluents as brown color or solid stool had a 54% chance of having fair or poor preparation. Thus, recent consensus guideline suggested consideration of additional oral preparation in patients presenting brown effluents on the day of colonoscopy. However, the data supporting additional oral preparation is still spares. Therefore, the investigators aimed to examine the impact of additional oral preparation on the quality of bowel preparation for colonoscopy in patients showing brown effluents on the day of colonoscopy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

156

Conditions

Bowel Preparation Quality

Interventions

Standard oral preparation (2L of PEG+Asc, "Coolprep®")DRUG

The control arm will receive currently used oral preparation (2l of PEG+Asc, "Coolprep®") for colonoscopy \* Compositions/1L : Sodium Chloride 2.691g Potassium Chloride 1.015g Anhydrous sodium sulfate 7.5g PEG 3350 100g ascorbic acid 4.7g sodium ascorbate 5.9g

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients who reporting their last rectal effluents as brown color or solid stool on the day colonoscopy Exclusion Criteria: * known hypersensitivity to polyethylene glycol * severe congestive heart failure \[New York Heart Association (NYHA) grade III or grade IV\] * severe renal insufficiency (creatinine clearance \<30 ml/min) * hemodynamic instability * suspected intestinal obstruction or perforation * compromised swallowing reflex or altered mental status * pregnancy or lactating woman * patients who declined to participate

Outcomes

Primary Outcomes

Quality of bowel preparation

The primary outcome will be the endoscopist's assessment of the quality of preparation using a standardized bowel preparation scale

Time frame: Day 1

Secondary Outcomes

Adenoma detection rate

Number of adenomatous polyps

Time frame: Day 1

Patient compliance

Patient compliance with preparation instructions self-reported in a pre-procedure questionnaire

Time frame: Baseline

Patient satisfaction

Patient's perception of the preparation method as self-reported on a pre-procedure questionnaire.