Premedication Simethione Improves Visibility During Bowel Cleansing for Colonoscopy

Changhai Hospital590 enrolled

Overview

To evaluate the efficacy, visibility of low volume polyethyleneglycol-simeticone (2-LPEG-S) for colonoscopy.

In this randomized controlled study, consecutive outpatients scheduled for elective colonoscopy were randomized into two groups. Group A patients (n = 300) used only 2 L PEG before colonoscopy. Patients in group B (n = 300) were additionally advised to simeticone plus 2 L PEG, The overall quality of colonoscopy cleaning was evaluated using the Boston Bowel Preparation Scale by a single endoscopist who was blinded to the intervention. Visibility was blindly assessed for the amount of air bubbles and adenoma detection rate (ADR). Difficulty of procedure, and adverse events were also evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

SINGLE

Enrollment

590

Conditions

Bowel Preparation Scale the Amount of Air Bubble Adenoma Detection Rate

Interventions

2L PEGDRUG

2L PEG+simethiconeDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients are between 18-65 years old * undergoing colonoscopy for diagnostic investigation, colorectal cancer screening or follow-up Exclusion Criteria: * suspected gastrointestinal obstruction or perforation * severe acute inflammatory bowel disease * toxic megacolon * ileus or gastric retention, ileostomy, * hypersensitivity to any of the ingredients * pregnancy and lactation and/or at a risk of becoming pregnant

Locations (1)

Changhai Hospital

Shanghai, Shanghai Municipality, China

Outcomes

Primary Outcomes

adenoma detection rate

Time frame: 2 days

bowel preparation scale

Time frame: 2 days

the amount of air bubbles

Five areas of the colon (rectosigmoid, descending, transverse, ascending, and cecum) were graded for the amount of air bubbles.The amount of intraluminal air bubbles was classified into four grades as shown below: Grade 0 = No or minimal scattered bubbles; Grade 1 = Bubbles covering at least half the luminal diameter; Grade 2 = Bubbles covering the circumference of the lumen; Grade 3 = Bubbles filling the entire lumen.

Time frame: 2 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.