Recurrence in High-grade Lesions After Conization

Faculdade de Medicina do ABC103 enrolled

Overview

Objectives: To identify factors associated with disease recurrence in patients with high-grade cervical intra-epithelial neoplasia (CIN) undergoing large loop excision of the transformation zone (LLETZ). Study Design: A case-control study that included 103 patients. Patients were included in the study if they had a history of surgery for conization by LLETZ for the histopathological diagnosis of cervical intraepithelial neoplasia grades II and III (CIN II and CIN III). Follow-up exams were conducted every six months with Pap smear collection and colposcopic examination with biopsy, when necessary, for a minimum period of twelve months. Cure was defined as a normal follow-up examination within 24 months. During follow-up, relapse occurred when cytology and/or biopsy results showed that CIN had returned after 12 months, at which time a new cervical conization by LLETZ was performed.

Study Type

OBSERVATIONAL

Enrollment

103

Conditions

Cervical Intraepithelial Neoplasia

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\. history of surgery for conization Exclusion Criteria: 1. under 18 years of age, 2. immunosuppressed, 3. Patient with a histopathological diagnosis of low-grade intraepithelial neoplasia 4. Patient with invasion, or surgical margins obtained by LLETZ that were unable to be evaluated.

Locations (1)

Outcomes

Primary Outcomes

Recurrence rates after conization

Number of patients who are regarded as recurrence based on the following criteria: \- relapse occurred when cytology and/or biopsy showed that CIN had returned after 12 months

Time frame: 12 months