The investigators tested the impact of purging the graft contents and mesenteric blood into the systemic circulation versus washing out this volume out of the circulation in living donor liver transplantation recipients.
All donors had right hepatectomy. On the back table, surgeons flushed liver grafts with 4 Liters of cold Custodiol solution. Patients were randomized into either purge group (Pg) (n=40) were graft fluid contents were washed out by the patient's portal vein blood (0.5ml per gram graft weight) through incompletely anastomosed hepatic vein, or No purge group (NPg) (n=40) where graft fluid contents were washed into the systemic circulation by the patient's portal blood. The primary outcome objective was the mean arterial blood pressure 5 minutes after portal declamping. Secondary objectives included hemodynamic and oxygenation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
80
In the recipient before portal declamping, the graft preservative solution and the mesenteric blood is washed out of the circulation into the abdominal cavity and sucked by external sucker through the incompletely anastomosed hepatic vein prior to portal declamping
Liver transplantation project - Gastroenterology surgical center - Mansoura university
Al Mansurah, Dakahlia Governorate, Egypt
Lowest 5 Minutes Post-reperfusion Mean Arterial Blood Pressure
The lowest of three recorded mean arterial pressure readings at 1,3 and 5 minutes after portal declamping
Time frame: 5 minutes post-reperfusion
Biliary Complications (Participants)
Participants who developed biliary complications in three months period (Participant)
Time frame: 3 months
Ischemia Reperfusion Injury
incidence of ischemia reperfusion injury in the transplanted graft
Time frame: 7 days
Post-operative Infectious Complications
Time frame: 30 days
3 Months Mortality
mortality within first 3 post-operative months
Time frame: 3 Months
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