The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen-In will provide an effective speech comprehension training tool that patients with aphasia can use to practice independently. This will free up therapists time to provide additional assessment, supervision and functional intervention in a highly cost effective manner.
The main aim is to develop and test the clinical efficacy of a novel, web based, rehabilitation application. Listen In will provide an effective speech comprehension training tool that patients can use to practice independently. This will free up SALT time to provide additional assessment, supervision and functional intervention in a highly cost effective manner. Phase 1 (24 months. London, Newcastle, Cambridge): Development of Listen In, including diagnostic and therapeutic components, driven by patient user's feedback (alpha and beta testing). The intervention is detailed below and is based on current SALT practice. It will be adaptive, provide feedback and target auditory perception at many levels: the phonemic, lexical and sentence level processing of heard verbal stimuli, as well as auditory short term memory and nonverbal sound discrimination. Phase 2 (12 months. London and Cambridge): A pilot, randomised, crossover, clinical trial of Listen-In in a group of aphasic patients in the chronic post-stroke period. A power calculation suggests that we will need 36 patents, 18 in each arm. The comparison will be standard SALT clinical care. The main outcome measure is a clinically relevant improvement on the comprehension of spoken language score of the Comprehensive Aphasia Test (Swinburn, 2004). Secondary outcomes include improvements in social activity and participation. The milestones for this phase will be: 50% recruitment into study and last patient, last visit. Phase 3 (funded outside i4i grant) will be the rollout of the therapy application on the internet with a pragmatic trial of whether therapy gains can be made outside the confines of a clinical trial. The comparison will be on similar outcome measures as Phase 2 with a control test on sustained attention (internal control) that we predict will not improve with therapy.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
36
100 hours of Auditory comprehension therapy embedded within a computer game.
UCLondon
London, United Kingdom
Improvement in auditory comprehension on the comprehensive aphasia test.
Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
Improvement in functional communication
Using patient reported outcomes to look at functional communication changes.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
Improvement in production of language
Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
Performance on the Sustained attention to response task
Investigation of improvement on sustained attention using the SART.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
Environmental sounds test
Investigation of improvement on the non verbal environmental sounds test.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
Test of semantics
Investigation of improvement in semantics knowledge.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
Improvement in written language comprehension
Investigation of improvement on a functionally relevant area of a widely used test of aphasia.
Time frame: Measured over 36 weeks (0,12,24,36) weeks
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Improvement on auditory descrimination
Investigation of improvement on a test of auditory discrimination developed by Dr Holly Robson.
Time frame: Measured over 36 weeks (0,12,24,36) weeks