Facioscapulohumeral muscular dystrophy (FSHD) is the second most common muscular dystrophy with approximately 500 patients in Denmark. It is characterized by weakness and wasting of the facial muscles, the muscles in the shoulder region and of the legs. The primary aim of this study is to investigate possible links and order between inflammation and fat infiltration in the muscles in patients with FSHD. Approximately 15 patients with FSHD will be recruited for repeated MRI-scans during a year where the inflammation and fat infiltration in the muscles can be quantified.
Study Type
OBSERVATIONAL
Enrollment
10
Copenhagen Neuromuscular Center
Copenhagen, Denmark
Muscle inflammation
MRI (t2 mapping) will be used to quantify the inflammation in skeletal muscle.
Time frame: One MRI scan per subject (exam lasts approximately 60 min.)
Muscle fat fraction
The Dixon MRI will be used to quantify the fat fraction in skeletal muscle.
Time frame: One MRI scan per subject (exam lasts approximately 60 min.)
Muscle strength
Isokinetic muscle dynamometry will be used to measure muscle strength.
Time frame: One muscle strength test per subject (exam lasts approximately 60 min.)
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